Martínez María Elena, Reid Mary, Jiang Ruiyun, Einspahr Janine, Alberts David S
Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Prev Med. 2004 Apr;38(4):492-7. doi: 10.1016/j.ypmed.2003.12.006.
Exposure to tobacco products is readily assessed through self- or interview-administered questionnaires. Degree of misreporting among participants in chemoprevention trials is unknown. We assessed the level of discrepancy between self-reported smoking exposure and plasma cotinine among participants in a chemoprevention trial.
Analyses were conducted among 824 men and women who participated in a dietary trial of adenoma recurrence. Smoking exposure was ascertained through self-administered questionnaires at three time-points. Plasma cotinine was measured by gas chromatography among 283 never, 446 former and 95 current self-reported smokers. Sensitivity and specificity were assessed using various plasma cotinine cut-points.
Degree of misclassification for self-reported current smokers was minor (0-3%), regardless of cotinine cut-point used. Using a cut-point of 20 ng/ml, which takes into account exposure to environmental tobacco smoke among nonsmokers, sensitivity and specificity were 98.9% and 80.2%, respectively.
These data indicate that degree of misreport for current smokers is extremely low; however, approximately 20% of self-reported never smokers misreport their exposure, suggesting that validation of self-report is needed for these individuals.
通过自我填写或访谈式问卷可轻松评估烟草制品暴露情况。化学预防试验参与者中误报的程度尚不清楚。我们评估了一项化学预防试验参与者自我报告的吸烟暴露情况与血浆可替宁之间的差异水平。
对824名参与腺瘤复发饮食试验的男性和女性进行了分析。在三个时间点通过自我填写问卷确定吸烟暴露情况。对283名自我报告从不吸烟、446名曾经吸烟和95名当前吸烟的参与者采用气相色谱法测量血浆可替宁。使用不同的血浆可替宁切点评估敏感性和特异性。
无论使用何种可替宁切点，自我报告当前吸烟者的错误分类程度都较小（0 - 3%）。使用20 ng/ml的切点（该切点考虑了非吸烟者接触环境烟草烟雾的情况），敏感性和特异性分别为98.9%和80.2%。
这些数据表明，当前吸烟者的误报程度极低；然而，约20%自我报告从不吸烟的人误报了他们的暴露情况，这表明这些个体需要对自我报告进行验证。
