糖尿病和非糖尿病患者腓肠神经中神经束膜细胞基底膜胶原蛋白IV、层粘连蛋白和纤连蛋白的定量分析
A quantitative analysis of perineurial cell basement membrane collagen IV, laminin and fibronectin in diabetic and non-diabetic human sural nerve.
作者信息
Hill R E, Williams R E
机构信息
Department of Biological Sciences, The University of Hull, UK.
出版信息
J Anat. 2002 Aug;201(2):185-92. doi: 10.1046/j.1469-7580.2002.00083.x.
Abstract
The thickness of the perineurial cell basement membrane was examined in diabetic and non-diabetic human sural nerve. A significant increase in thickness was found in the diabetic group. The nature of this thickening was investigated using immunohistochemistry and image analysis in order to semi-quantify three of the major intrinsic components of the perineurial cell basement membrane: collagen IV, laminin and fibronectin. Amounts of all three components were shown to be increased in the diabetic group, but not significantly so. However, significant linear correlations between fascicle size and perineurial collagen IV, laminin and fibronectin were identified in both diabetic and non-diabetic nerve.
摘要
在糖尿病患者和非糖尿病患者的腓肠神经中检测了神经束膜细胞基底膜的厚度。发现糖尿病组的厚度显著增加。为了对神经束膜细胞基底膜的三种主要内在成分（IV型胶原、层粘连蛋白和纤连蛋白）进行半定量分析，采用免疫组织化学和图像分析研究了这种增厚的性质。结果显示，糖尿病组中所有这三种成分的含量均有所增加，但增加并不显著。然而，在糖尿病神经和非糖尿病神经中均发现，神经束大小与神经束膜IV型胶原、层粘连蛋白和纤连蛋白之间存在显著的线性相关性。
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