Muona P, Peltonen J
Department of Medical Biochemistry, University of Turku, Finland.
Ann Med. 1994 Feb;26(1):39-43. doi: 10.3109/07853899409147325.
Diabetes mellitus is associated with multiple connective tissue changes, such as generalized thickening of basement membranes. These alterations are suspected of contributing to the development of diabetic long-term complications encountered in many organs, including kidney, eye and peripheral nerves. The latter tissue, however, has gained relatively little attention with respect to connective tissue changes associated with diabetes. The morphological alterations of connective tissue in the diabetic peripheral nerve include thickening of basement membranes, increased diameter of endoneurial collagen fibrils, and accumulation of microfibrillar material. Recent studies have further elucidated the changes in the extracellular matrix of diabetic nerves and the molecular mechanisms underlying these alterations. For instance, elevated glucose concentrations modulate the expression of several proteins of the extracellular matrix in cultured nerve-derived connective tissue cells. In this article, we review the recent progress in the field of connective tissue alterations in diabetes and particularly in the diabetic peripheral nerve.
糖尿病与多种结缔组织变化相关，如基底膜普遍增厚。这些改变被怀疑与糖尿病在许多器官（包括肾脏、眼睛和周围神经）中出现的长期并发症的发生有关。然而，就与糖尿病相关的结缔组织变化而言，后一种组织受到的关注相对较少。糖尿病周围神经中结缔组织的形态学改变包括基底膜增厚、神经内膜胶原纤维直径增加以及微纤维物质的积累。最近的研究进一步阐明了糖尿病神经细胞外基质的变化以及这些改变背后的分子机制。例如，升高的葡萄糖浓度可调节培养的神经源性结缔组织细胞中几种细胞外基质蛋白的表达。在本文中，我们综述了糖尿病尤其是糖尿病周围神经结缔组织改变领域的最新进展。
