Carroll Kathleen M, Farentinos Chris, Ball Samuel A, Crits-Christoph Paul, Libby Bryce, Morgenstern Jon, Obert Jeanne L, Polcin Doug, Woody George E
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA.
J Subst Abuse Treat. 2002 Sep;23(2):73-80. doi: 10.1016/s0740-5472(02)00255-6.
The Clinical Trials Network (CTN) represents a major initiative intended to bridge the gap between research and practice in substance abuse treatment by implementing a range of studies evaluating behavioral, pharmacologic, and combined treatments in community-based drug abuse treatment programs across the country. This article describes the development of CTN protocols evaluating the effectiveness of Motivational Enhancement Therapy and Motivational Interviewing. Design, training, and implementation challenges associated with conducting a clinical trial of brief behavioral treatments in community programs are discussed. Issues requiring attention included the diversity in treatments offered across sites, heterogeneity in the study sample, and training of clinicians drawn from the staff of community programs to deliver the study treatments.
临床试验网络（CTN）是一项重大举措，旨在通过开展一系列研究来弥合药物滥用治疗研究与实践之间的差距，这些研究评估了全国社区药物滥用治疗项目中的行为治疗、药物治疗及联合治疗。本文描述了评估动机增强疗法和动机访谈有效性的CTN方案的制定过程。讨论了在社区项目中进行简短行为治疗临床试验所涉及的设计、培训和实施挑战。需要关注的问题包括各站点提供的治疗方法的多样性、研究样本的异质性，以及培训来自社区项目工作人员的临床医生以提供研究治疗。
