Domínguez Fernández E, Suchan K L, Gerke B, Rössner E, Post S, Manegold B C
Chirurgische Klinik, Fakultät für Klinische Medizin Mannheim, Universität Heidelberg.
Zentralbl Chir. 2002 Sep;127(9):786-90. doi: 10.1055/s-2002-33959.
Indication for emergency ERCP (< 48 hours after onset of symptoms) with stone extraction from the common bile duct (CBD) in patients with biliary pancreatitis remains controversial. In our hospital emergency ERCP with stone extraction from CBD is part of the therapeutical concept in patients with biliary pancreatitis. The aim of the study was to elucidate retrospectively results and impact of this concept on morbidity and lethality in surgical intensive care patients. We included all patients with a documented indication for emergency ERCP. Among 4 466 patients (1. 1. 1999-31. 12. 2000) treated in the SICU, 37 (0.9 %) required an emergency ERCP due to a biliary pancreatitis. (26 females/11 males, 62.0 +/- 15.4 years). After ERCP stones were present in 32 of the 37 patients with subsequent successful endoscopic extraction in all cases but one. The mean duration from admission to ERCP was 11.6 +/- 10.1 hours. Bilirubin as well as amylase and lipase decreased after ERCP (p < 0.05). Only in one case an elevation of pancreatic enzymes over the pre-ERCP values was observed, an aggravation of pancreatitis was not seen in our series. In 5 of the 37 cases bile duct stones were not found after ERCP despite strong clinical suggestion (elevation of bilirubin and pancreatic enzymes, ultrasound). During the observational period 2 patients died, in one case possibly due to the ERCP. Emergency ERCP removed in our series the pancreatitis causing agent. Still considering the limitations of a retrospective study these positive results are stimulating us to continue with our therapeutical concept.
对于胆源性胰腺炎患者,在症状发作后48小时内进行急诊内镜逆行胰胆管造影术(ERCP)并从胆总管(CBD)取石的指征仍存在争议。在我们医院,急诊ERCP并从CBD取石是胆源性胰腺炎患者治疗理念的一部分。本研究的目的是回顾性地阐明这一理念对外科重症监护患者发病率和死亡率的影响及结果。我们纳入了所有有急诊ERCP记录指征的患者。在1999年1月1日至2000年12月31日期间在外科重症监护病房(SICU)接受治疗的4466例患者中,37例(0.9%)因胆源性胰腺炎需要进行急诊ERCP。(26例女性/11例男性,年龄62.0±15.4岁)。ERCP后,37例患者中有32例发现结石,除1例病例外,所有病例随后均成功进行了内镜取石。从入院到ERCP的平均时间为11.6±10.1小时。ERCP后胆红素以及淀粉酶和脂肪酶水平下降(p<0.05)。仅1例观察到胰腺酶水平高于ERCP前值,在我们的系列研究中未发现胰腺炎加重情况。37例病例中有5例尽管临床强烈提示(胆红素和胰腺酶升高、超声检查),但ERCP后未发现胆管结石。在观察期内,2例患者死亡,1例可能与ERCP有关。在我们的系列研究中,急诊ERCP清除了引起胰腺炎的病因。尽管考虑到回顾性研究的局限性,但这些积极结果促使我们继续采用我们的治疗理念。