Kahan A, Alcalay M, Amor B, Delbarre F
Biomedicine. 1975 Apr 10;23(3):111-5.
The antigenicity of aqueous extracts of osteoarthritic and rheumatoid synoviale was studied in patients with rheumatoid arthritis, other diseases and in normal controls by the mean of leucocyte migration test, lymphoblastic transformation test and cutaneous reactions. In 59% cases of rheumatoid arthritis an inhibition of the migration of leucocytes was found but there was no relation between this test and the clinical state, the evolution, rheumatoid serology and other laboratory parameters. In some cases of rheumatoid arthritis an inhibition of the migration of leucocytes was observed also with a pericardial and hepatic extract. In normal controls the leucocyte migration test is always negative, but it is positive in 37% of cases of various inflammatory and neoplastic diseases and the difference is not significant considering the percentage of positivity of the test in rheumatoid arthritis. The lymphoblastic transformation test and the cutaneous reactions were always negative in rheumatoid arthritis and in controls. Thus, the leucocyte migration test using a synovial extract as an antigen does not bring evidence in favour of an auto-immune conflict in rheumatoid arthritis.
通过白细胞迁移试验、淋巴细胞转化试验和皮肤反应，对类风湿关节炎患者、其他疾病患者及正常对照者研究了骨关节炎和类风湿性滑膜炎水提取物的抗原性。在59%的类风湿关节炎病例中发现白细胞迁移受到抑制，但该试验与临床状态、病情演变、类风湿血清学及其他实验室参数之间并无关联。在某些类风湿关节炎病例中，心包和肝提取物也观察到白细胞迁移受到抑制。在正常对照者中，白细胞迁移试验始终为阴性，但在37%的各种炎症性和肿瘤性疾病病例中为阳性，考虑到该试验在类风湿关节炎中的阳性率，差异并不显著。类风湿关节炎患者和对照者的淋巴细胞转化试验及皮肤反应始终为阴性。因此，以滑膜提取物作为抗原的白细胞迁移试验并未为类风湿关节炎中的自身免疫冲突提供证据。
