Morgan J E, Hall N D, Collins A J, Bacon P A
Ann Rheum Dis. 1980 Aug;39(4):323-8. doi: 10.1136/ard.39.4.323.
The leucocyte migration inhibition test (LMT) has been used to search for specific antigens in rheumatoid synovial tissue. Synovial samples were collected from 20 patients with rheumatoid arthritis, from 1 patient with ankylosing spondylitis, and from 1 patient with pigmented villonodular synovitis. Inhibitory material was obtained from all 21 synovia with inflammatory disease but not from the noninflammatory synovium. The tissue extracts generally caused nonspecific migration inhibition when tested against a total of 157 pairs of rheumatoid and control leucocytes. However, occasional samples did induce migration inhibition restricted to either rheumatoid or control cells. The inhibitory factor was shown to be membrane associated and of high molecular weight (greater than 10(6) daltons). The results of this extensive study do not support the conclusions drawn from earlier reports based on smaller numbers of experiments. No evidence was obtained for the existence of specific antigenic material associated with the synovial membrane in rheumatoid arthritis.
白细胞游走抑制试验（LMT）已被用于在类风湿性滑膜组织中寻找特定抗原。从20例类风湿性关节炎患者、1例强直性脊柱炎患者和1例色素沉着绒毛结节性滑膜炎患者身上采集滑膜样本。从所有21例患有炎性疾病的滑膜中获得了抑制物质，但未从非炎性滑膜中获得。当用总共157对类风湿性和对照白细胞进行测试时，组织提取物通常会引起非特异性游走抑制。然而，偶尔有样本确实会诱导仅对类风湿性或对照细胞的游走抑制。抑制因子显示与膜相关且分子量较大（大于10^6道尔顿）。这项广泛研究的结果不支持基于较少数量实验的早期报告得出的结论。没有获得证据表明类风湿性关节炎中存在与滑膜相关的特异性抗原物质。
