Sheffield Leslie J
Genetic Health Services Victoria, Murdoch Childrens Research Institute, University of Melbourne, Melbourne, Australia.
Pharmacogenomics. 2002 Sep;3(5):679-86. doi: 10.1517/14622416.3.5.679.
There has been a great increase in the knowledge of understanding the genetic basis for individual variation in response to drugs. The study of variation in gene structure (polymorphism) can now predict the likely metabolic behavior in an individual for a number of drugs. This review documents the different strategies that can be used to find new genes and polymorphisms within these genes. Candidate genes can be used in case-control studies or studies where the parents of the person having an adverse effect from the drug are used as controls. New genes are being discovered in the drug development process and the technological development in molecular biology is expected to greatly enhance knowledge of the genes that regulate drug metabolism.
在理解药物反应个体差异的遗传基础方面，已有大量知识积累。基因结构变异（多态性）研究如今能够预测个体对多种药物可能的代谢行为。本综述记录了可用于发现新基因及其内部多态性的不同策略。候选基因可用于病例对照研究，或在将因药物产生不良反应者的父母用作对照的研究中使用。在药物研发过程中不断有新基因被发现，分子生物学的技术发展有望极大地增进对调控药物代谢基因的认识。
