Ishikawa N, Awaya Y, Maeda H, Miyazaki M, Fujitaka K, Yamasaki M, Kondo K, Oguri T, Isobe T, Kohno N
Second Department of Internal Medicine, Hiroshima University Faculty of Medicine, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Ann Hematol. 2002 Aug;81(8):474-7. doi: 10.1007/s00277-002-0465-4. Epub 2002 Jul 31.
A 59-year-old woman was admitted to our hospital complaining of a productive cough, dyspnea on effort, and low-grade fever. Although chest X-rays showed no marked abnormalities, her level of serum KL-6 was extremely high. We therefore suspected the presence of interstitial pneumonia. High-resolution computed tomography (CT) scan revealed infiltrative shadows in S6 of the right lung, and her serum was positive for antihuman T-lymphotropic virus type 1 (HTLV-1) antibodies. From the clinical symptoms, radiographic findings, and histological findings, the diagnosis was probable lymphocytic interstitial pneumonia (LIP). After high-dose corticosteroid therapy, the level of serum KL-6 decreased rapidly. We conclude that KL-6 is a convenient and reliable marker for evaluating the activity of pulmonary manifestations in HTLV-1 carriers and that it is especially useful in monitoring the effectiveness of treatments.
一名59岁女性因咳嗽、咳痰、劳力性呼吸困难及低热入院。尽管胸部X线检查未发现明显异常，但她的血清KL-6水平极高。因此，我们怀疑存在间质性肺炎。高分辨率计算机断层扫描（CT）显示右肺S6有浸润影，且她的血清抗人类嗜T淋巴细胞病毒1型（HTLV-1）抗体呈阳性。根据临床症状、影像学表现及组织学检查结果，诊断可能为淋巴细胞间质性肺炎（LIP）。大剂量糖皮质激素治疗后，血清KL-6水平迅速下降。我们得出结论，KL-6是评估HTLV-1携带者肺部表现活动度的便捷且可靠的标志物，尤其在监测治疗效果方面很有用。
