Forutan F, Estalji S, Beu M, Nikolaus S, Hamacher K, Coenen H H, Vosberg H, Müller-Gärtner H W, Larisch R
Klinik für Nuklearmedizin, Heinrich-Heine-Universität Düsseldorf, Deutschland.
Nuklearmedizin. 2002;41(4):197-201.
The study presented here firstly compares the distribution of the binding potential of the serotonin-5HT2A receptor as measured in vivo with data of receptor density taken from literature. Secondly, the sensitivity of the method to detect gradual differences in receptor densities is evaluated.
Positron emission tomography (PET) studies were carried out in 6 healthy volunteers using the selective serotonin-5HT2A ligand 18F-altanserin. The binding potential was quantified in 12 regions using Logan's graphical method and the equilibrium method. These data were compared to the distribution of receptor density as taken from literature.
The binding data in vivo correlated to autoradiography data (post mortem) with r = 0.83 (Pearson regression coefficient; p < 0.0001). A difference in the receptor density between two regions could be detected with p < 0.05 when it amounted at least to 18%.
This study demonstrates a good agreement between in vivo data obtained with 18F-altanserin and PET in healthy volunteers and the true autoradiographically determined distribution of 5HT2A receptors in human brains. The in vivo method seems to be sensitive enough to detect changes in receptor density of more than 18%.
本研究首先比较了体内测量的血清素-5HT2A受体结合潜能分布与文献中受体密度数据。其次，评估该方法检测受体密度逐渐差异的敏感性。
使用选择性血清素-5HT2A配体18F-阿坦色林对6名健康志愿者进行正电子发射断层扫描（PET）研究。使用洛根图解法和平衡法在12个区域对结合潜能进行定量。将这些数据与文献中的受体密度分布进行比较。
体内结合数据与放射自显影数据（死后）相关，r = 0.83（皮尔逊回归系数；p < 0.0001）。当两个区域的受体密度差异至少达到18%时，可检测到差异，p < 0.05。
本研究表明，在健康志愿者中使用18F-阿坦色林和PET获得的体内数据与通过放射自显影确定的人脑中5HT2A受体真实分布具有良好的一致性。体内方法似乎足够敏感，能够检测到超过18%的受体密度变化。
