Rosier A, Dupont P, Peuskens J, Bormans G, Vandenberghe R, Maes M, de Groot T, Schiepers C, Verbruggen A, Mortelmans L
Laboratory for Neuro- and Psychophysiology, Medical School, K.U. Leuven, Belgium.
Psychiatry Res. 1996 Nov 25;68(1):11-22. doi: 10.1016/s0925-4927(96)02806-5.
We used [18F]altanserin and positron emission tomography (PET) to image serotonin 5-HT2A receptors in humans. The highest [18F]altanserin uptake is found in the cerebral cortex, with specific-to-nonspecific binding ratios varying from 0.53 to 1.91 in humans between 24 and 48 years of age. In all neocortical regions studied, [18F]altanserin uptake correlates negatively with age. No correlations were found between age and uptake in the cerebellum, the regional cerebral blood flow, or the time course of metabolization of [18F]altanserin. The reduction in cerebral 5-HT2A receptor binding thus directly reflects the loss of specific 5-HT2A receptors with age.
我们使用[18F]阿坦色林和正电子发射断层扫描（PET）对人类血清素5-HT2A受体进行成像。在大脑皮层中发现[18F]阿坦色林摄取量最高，24至48岁的人类中特异性与非特异性结合比率在0.53至1.91之间变化。在所有研究的新皮质区域中，[18F]阿坦色林摄取量与年龄呈负相关。在小脑、局部脑血流量或[18F]阿坦色林代谢的时间进程中，未发现年龄与摄取量之间存在相关性。因此，大脑5-HT2A受体结合的减少直接反映了随着年龄增长特异性5-HT2A受体丢失的情况。
