Fouet A, Mesnage S
Toxines et Pathogénie Bactériennes (URA 2172, CNRS), Institut Pasteur, 28 rue du Dr Roux, 75724, Paris, France.
Curr Top Microbiol Immunol. 2002;271:87-113. doi: 10.1007/978-3-662-05767-4_5.
Bacillus anthracis is a Gram-positive bacterium harboring a complex parietal architecture. The cytoplasmic membrane is surrounded by a thick peptidoglycan of the A1 gamma type. Only one associated polymer, a polysaccharide composed of galactose, N-acetylglucosamine, and N-acetylmannosamine, is covalently linked to the peptidoglycan. Outside the cell wall is an S-layer. Two proteins can each compose the S-layer. They are noncovalently anchored to the cell wall polysaccharide by their SLH N-terminal domain. The poly-gamma-D-glutamate capsule, which covers the S-layer, has an antiphagocytic role and its synthesis is dependent on environmental factors mimicking the mammalian host, such as bicarbonate and a temperature of 37 degrees C.
炭疽芽孢杆菌是一种具有复杂细胞壁结构的革兰氏阳性细菌。细胞质膜被A1γ型厚肽聚糖包围。只有一种与之相关的聚合物，即由半乳糖、N-乙酰葡糖胺和N-乙酰甘露糖胺组成的多糖，与肽聚糖共价连接。细胞壁外是一层S层。两种蛋白质均可构成S层。它们通过其SLH N端结构域非共价锚定在细胞壁多糖上。覆盖S层的聚-γ-D-谷氨酸荚膜具有抗吞噬作用，其合成取决于模拟哺乳动物宿主的环境因素，如碳酸氢盐和37摄氏度的温度。
