De Korte John, Mombers Femke M C, Sprangers Mirjam A G, Bos Jan D
Department of Dermatology, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands.
Arch Dermatol. 2002 Sep;138(9):1221-7; discussion 1227. doi: 10.1001/archderm.138.9.1221.
To critically appraise the suitability of current quality-of-life (QOL) questionnaires for psoriasis research.
Computerized searches of 5 bibliographic databases. QUESTIONNAIRE SELECTION: Predefined criteria were used to identify QOL questionnaires in dermatologic studies. Two investigators independently assessed and agreed on multidimensional generic, dermatology-specific, and psoriasis-specific QOL questionnaires for inclusion.
Data were extracted on the internal structure, reliability, and validity of the included questionnaires.
Three generic, 3 dermatology-specific, and none of the psoriasis-specific questionnaires met the inclusion criteria: the Nottingham Health Profile (NHP), the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), the Sickness Impact Profile (SIP), the Dermatology Quality of Life Scales (DQOLS), the Dermatology-Specific Quality of Life Instrument (DSQL), and the Skindex-29. The generic NHP, SF-36 and SIP are well established, reliable, and valid. Although the data are not conclusive, the SF-36 was useful to assess effects of psoriasis on its component scales. The dermatology-specific DQOLS, DSQL, and Skindex-29 are relatively new and, therefore, less widely tested. Available psychometric data demonstrated the reliability and validity of all 3 dermatology-specific questionnaires. The Skindex-29 was also useful to assess change.
None of the identified psoriasis-specific questionnaires met the inclusion criteria. Data on the suitability of the included questionnaires for psoriasis research were relatively sparse. The included generic questionnaires allow comparisons with nondermatologic diseases but do not allow assessment of relevant dermatology-specific aspects and are not sensitive to subtle effects of psoriasis on QOL. On the basis of the psychometric data of the present review, we find the Skindex-29 to be the most valuable dermatology-specific questionnaire for psoriasis research. Combination of the Skindex-29 with the generic SF-36 combines the merits of both types of questionnaires and we therefore recommend this combination.
严格评估当前用于银屑病研究的生活质量（QOL）问卷的适用性。
对5个文献数据库进行计算机检索。问卷选择：使用预定义标准来识别皮肤病学研究中的QOL问卷。两名研究人员独立评估并就纳入的多维通用、皮肤病学特异性和银屑病特异性QOL问卷达成一致。
提取所纳入问卷的内部结构、信度和效度数据。
3份通用问卷、3份皮肤病学特异性问卷以及无银屑病特异性问卷符合纳入标准：诺丁汉健康量表（NHP）、医学结局研究简明健康调查36项量表（SF - 36）、疾病影响量表（SIP）、皮肤病生活质量量表（DQOLS）、皮肤病特异性生活质量量表（DSQL）和皮肤病生活质量指数 - 29（Skindex - 29）。通用的NHP、SF - 36和SIP已确立、可靠且有效。尽管数据尚无定论，但SF - 36有助于评估银屑病对其各个分量表的影响。皮肤病学特异性的DQOLS、DSQL和Skindex - 29相对较新，因此测试范围较窄。现有的心理测量数据证明了这3份皮肤病学特异性问卷的信度和效度。Skindex - 29也有助于评估变化情况。
所识别的银屑病特异性问卷均未符合纳入标准。关于所纳入问卷用于银屑病研究适用性的数据相对较少。所纳入的通用问卷可用于与非皮肤病疾病进行比较，但无法评估相关的皮肤病学特异性方面，且对银屑病对生活质量的细微影响不敏感。基于本综述的心理测量数据，我们发现Skindex - 29是用于银屑病研究最有价值的皮肤病学特异性问卷。将Skindex - 29与通用的SF - 36相结合可兼具两种问卷的优点，因此我们推荐这种组合。
