He Zehui, Lu Chuanjian, Chren Mary-Margaret, Zhang Zhongzhao, Li Yan, Ni Xiaojia, Buchtel V Henry A, Ryan Paul F, Li Guo-Zheng
Department of Clinical Epidemiology, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Department of Dermatology, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, No.111 Da De Road, Guangdong, 510120, China.
Health Qual Life Outcomes. 2014 Dec 24;12:190. doi: 10.1186/s12955-014-0190-4.
Dermatological disease significantly affects patient's health-related quality of life (HrQoL). Skindex is one of the most frequently used dermatology-specific HrQoL measures. Currently no Chinese version of Skindex is available. The aim of this study was to translate and culturally adapt Skindex-29 and Skindex-16 into Chinese, and to evaluate their reliability and validity.
Translation and cultural adaption were performed following guidelines for cross-cultural adaption of health-related quality of life measures. Subsequently, a cross-sectional study was conducted in which patients with dermatological disease (n = 225) were enrolled. The Chinese version of Skindex-29 and Skindex-16 and Dermatology Life Quality Index (DLQI) were completed. Reliability was evaluated with internal consistency using Cronbach's alpha. Validity was evaluated using known-groups validity, convergent validity and factor structure validity.
There were both seven items of Skindex-29 and Skindex-16 requiring a second forward- and backward- translation to achieve the final satisfactory Chinese version. The internal consistency reliability was high (range of Cronbach's alpha for the scales of Skindex-29 0.85-0.97, Skindex-16 0.86-0.96). Known-group validity was demonstrated by higher scores from patients with inflammatory dermatosis than from patients with isolated skin lesions (P < 0.05). Evidence of factor structure validity of the Skindex-29 and Skindex-16 was demonstrated by both exploratory factor analysis that accounted for 68.66% and 77.78% of the total variance, respectively, and confirmatory factor analysis with acceptable fitness into the expected three-factor structure.
This study has developed semantically equivalent translations of Skindex-29 and Skindex-16 into Chinese. The evaluation of the instruments' psychometric properties shows they have substantial evidence of reliability and validity for use as HrQoL instruments in Chinese patients with dermatological disease.
皮肤病严重影响患者的健康相关生活质量（HrQoL）。Skindex是最常用的皮肤病特异性HrQoL测量工具之一。目前尚无Skindex的中文版。本研究旨在将Skindex-29和Skindex-16翻译成中文并进行文化调适，并评估其信度和效度。
按照健康相关生活质量测量工具跨文化调适指南进行翻译和文化调适。随后，开展了一项横断面研究，纳入了皮肤病患者（n = 225）。完成了Skindex-29和Skindex-16的中文版以及皮肤病生活质量指数（DLQI）。使用Cronbach's α系数通过内部一致性评估信度。使用已知群体效度、收敛效度和因子结构效度评估效度。
Skindex-29和Skindex-16均有7个条目需要再次进行正向和反向翻译以获得最终满意的中文版。内部一致性信度较高（Skindex-29量表的Cronbach's α系数范围为0.85 - 0.97，Skindex-16为0.86 - 0.96）。炎症性皮肤病患者的得分高于孤立性皮肤病变患者，证明了已知群体效度（P < 0.05）。探索性因子分析分别解释了总方差的68.66%和77.78%，验证性因子分析显示与预期的三因子结构拟合良好，证明了Skindex-29和Skindex-16的因子结构效度。
本研究已将Skindex-29和Skindex-16翻译成语义等效的中文版本。对这些工具心理测量特性的评估表明，它们有充分的信度和效度证据，可作为中国皮肤病患者的HrQoL工具使用。
