系统性红斑狼疮中树突状细胞亚群的相互作用。

The interplay of dendritic cell subsets in systemic lupus erythematosus.

作者信息

Palucka A Karolina, Banchereau Jacques, Blanco Patrick, Pascual Virginia

机构信息

Baylor Institute for Immunology Research and University of Texas Southwestern Medical Center, Dallas 75204, USA.

出版信息

Immunol Cell Biol. 2002 Oct;80(5):484-8. doi: 10.1046/j.1440-1711.2002.01112.x.

DOI:10.1046/j.1440-1711.2002.01112.x

PMID:12225385

Abstract

Dendritic cells (DC) control immunity and tolerance. Hence, we surmised that systemic lupus erythematosus (SLE), a systemic autoimmune disease with autoreactive T and B cells, might be due to DC alterations. Based on our findings, we are proposing a model of SLE where autoimmune responses are driven by unabated activation of myeloid DC through IFN-alpha produced by plasmacytoid DC. Thus, interplay between DC subsets might represent a key component of SLE pathogenesis.

摘要

树突状细胞（DC）控制免疫和耐受性。因此，我们推测系统性红斑狼疮（SLE），一种伴有自身反应性T细胞和B细胞的全身性自身免疫性疾病，可能是由于DC改变所致。基于我们的研究结果，我们提出了一种SLE模型，其中自身免疫反应是由浆细胞样DC产生的IFN-α导致髓样DC持续激活所驱动的。因此，DC亚群之间的相互作用可能代表了SLE发病机制的一个关键组成部分。