Al Gadban Mohammed M, Alwan Mohamed M, Smith Kent J, Hammad Samar M
Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA.
Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA.
Clin Immunol. 2015 Apr;157(2):133-44. doi: 10.1016/j.clim.2015.01.008. Epub 2015 Jan 28.
Atherosclerosis is a chronic inflammatory condition that is considered a major cause of death worldwide. Striking phenomena of atherosclerosis associated with systemic lupus erythematosus (SLE) is its high incidence in young patients. Macrophages are heterogeneous cells that differentiate from hematopoietic progenitors and reside in different tissues to preserve tissue integrity. Macrophages scavenge modified lipids and play a major role in the development of atherosclerosis. When activated, macrophages secret inflammatory cytokines. This activation triggers apoptosis of cells in the vicinity of macrophages. As such, macrophages play a significant role in tissue remodeling including atherosclerotic plaque formation and rupture. In spite of studies carried on identifying the role of macrophages in atherosclerosis, this role has not been studied thoroughly in SLE-associated atherosclerosis. In this review, we address factors released by macrophages as well as extrinsic factors that may control macrophage behavior and their effect on accelerated development of atherosclerosis in SLE.
动脉粥样硬化是一种慢性炎症性疾病，被认为是全球主要的死亡原因。与系统性红斑狼疮（SLE）相关的动脉粥样硬化的显著现象是其在年轻患者中的高发病率。巨噬细胞是异质性细胞，它们从造血祖细胞分化而来，存在于不同组织中以维持组织完整性。巨噬细胞清除修饰的脂质，并在动脉粥样硬化的发展中起主要作用。激活后，巨噬细胞分泌炎性细胞因子。这种激活触发巨噬细胞附近细胞的凋亡。因此，巨噬细胞在包括动脉粥样硬化斑块形成和破裂在内的组织重塑中起重要作用。尽管已经开展了多项研究来确定巨噬细胞在动脉粥样硬化中的作用，但在SLE相关的动脉粥样硬化中，这一作用尚未得到充分研究。在这篇综述中，我们探讨了巨噬细胞释放的因子以及可能控制巨噬细胞行为的外在因素，及其对SLE中动脉粥样硬化加速发展的影响。
