Zimerson Erik, Bruze Magnus
Department of Occupational and Environmental Dermatology, Malmö University Hospital, Malmö,
Contact Dermatitis. 2002 Jul;47(1):40-6. doi: 10.1034/j.1600-0536.2002.470108.x.
Contact allergy to p-tert-butylphenol formaldehyde resin (PTBP-F-R) is not rare. This resin consists of a large number of substances, most of which are still unknown. For diagnostic and preventive reasons the chemical identity of the sensitizers should be known, as well as their sensitizing capacities, cross-reaction patterns and presence in the environment. The aims of this study were to investigate the sensitizing capacities and potential cross-reacting patterns for 4-tert-butyl- 2,6-bis-(5-tert-butyl-2-hydroxy-3-hydroxymethyl-benzyloxymethyl)-phenol (XIII), 4-tert-butyl-2- (5 - tert - butyl - 2 - hydroxy-benzyloxymethyl) - 6 - (5 - tert - butyl - 2 - hydroxy - 3 - hydroxymethyl-benzyloxy methyl)-phenol (XIVa) and 7,15,23-tri-tert-butyl-25,26,27-trihydroxy-2,3,10,11,18,19-hexahomo-3,11,19-trioxacalix(3)arene (XVIII) by the guinea pig maximization test. 4-tert-Butyl-2,6-bis-hydroxymethyl-phenol, 4-tert-butylbenzene-1,2-diol, 4-tert-butyl-2-hydroxymethyl-phenol, 4-tert-butyl-phenol, 4-tert-butyl-2-(5-tert-butyl-2-hydroxy-3-hydroxymethyl-benzyloxymethyl)-6-hydroxymethyl-phenol, 4-tert-butyl-2-[5-tert-butyl-3-(5-tert-butyl-2-hydroxy-3-hydroxymethyl-benzyloxymethyl) - 2 -hydroxy-benzyloxymethyl] - 6 - (5 - tert-butyl- 2 -hydroxy- 3 -hydroxymethyl-benzyloxymethyl)- phenol and were used as potential cross-reacting substances. In this study it is strongly indicated that the linear trimer XIII has a sensitizing capacity in the guinea pig which was significant when compared to the controls (p = 0.024). No cross-reactions were detected in animals induced with the linear trimer XIII. The linear trimer XIVa and the cyclic trimer XVIII failed to induce sensitization.
对对叔丁基苯酚甲醛树脂（PTBP - F - R）的接触性过敏并不罕见。这种树脂由大量物质组成，其中大多数仍然未知。出于诊断和预防的原因，致敏剂的化学特性、它们的致敏能力、交叉反应模式以及在环境中的存在情况都应该为人所知。本研究的目的是通过豚鼠最大化试验研究4 - 叔丁基 - 2,6 - 双 -（5 - 叔丁基 - 2 - 羟基 - 3 - 羟甲基 - 苄氧基甲基） - 苯酚（XIII）、4 - 叔丁基 - 2 -（5 - 叔丁基 - 2 - 羟基 - 苄氧基甲基） - 6 -（5 - 叔丁基 - 2 - 羟基 - 3 - 羟甲基 - 苄氧基甲基） - 苯酚（XIVa）和7,15,23 - 三叔丁基 - 25,26,27 - 三羟基 - 2,3,10,11,18,19 - 六高 - 3,11,19 - 三氧杂杯[3]芳烃（XVIII）的致敏能力和潜在的交叉反应模式。4 - 叔丁基 - 2,6 - 双 - 羟甲基 - 苯酚、4 - 叔丁基苯 - 1,2 - 二醇、4 - 叔丁基 - 2 - 羟甲基 - 苯酚、4 - 叔丁基 - 苯酚、4 - 叔丁基 - 2 -（5 - 叔丁基 - 2 - 羟基 - 3 - 羟甲基 - 苄氧基甲基） - 6 - 羟甲基 - 苯酚、4 - 叔丁基 - 2 - [5 - 叔丁基 - 3 -（5 - 叔丁基 - 2 - 羟基 - 3 - 羟甲基 - 苄氧基甲基） - 2 - 羟基 - 苄氧基甲基] - 6 -（5 - 叔丁基 - 2 - 羟基 - 3 - 羟甲基 - 苄氧基甲基） - 苯酚被用作潜在的交叉反应物质。在本研究中，强烈表明线性三聚体XIII在豚鼠中具有致敏能力，与对照组相比具有显著性（p = 0.024）。在用线性三聚体XIII诱导的动物中未检测到交叉反应。线性三聚体XIVa和环状三聚体XVIII未能诱导致敏。
