Zimerson E, Bruze M
Department of Occupational and Environmental Dermatology, University Hospital Malmö, Sweden.
Contact Dermatitis. 1998 Nov;39(5):222-6. doi: 10.1111/j.1600-0536.1998.tb05913.x.
In patients hypersensitive to p-tert-butylphenol-formaldehyde resin (PTBP-F-R), and butylphenol derivatives therein, it is for diagnostic, therapeutic and preventive reasons necessary to know the identity of the primary sensitizing substances, their sensitizing capacities as well as their cross-reaction patterns. The monomers in PTBP-F-R, 2-methylol p-tert-butylphenol (2-MPTBP) and 2,6-dimethylol p-tert-butylphenol (2,6-MPTBP), have been shown to be contact sensitizers in man. The aim of this study was to investigate the sensitizing capacities of the monomers and establish cross-reacting patterns in the guinea pig with the guinea pig maximization test. 2,6-MPTBP was shown to be a strong sensitizer while it was indicated that 2-MPTBP was a sensitizer. Animals sensitized to 2,6-MPTBP showed cross-reactions to 2-MPTBP and p-tert-butylcatechol. No cross-reactions were shown to p-tert-butylphenol, tert-butyl 4-hydroxyanisole (BHA) and 3,5-di-tert-butyl 4-hydroxytoluene (BHT).
对于对对叔丁基苯酚甲醛树脂（PTBP - F - R）及其所含丁基苯酚衍生物过敏的患者，出于诊断、治疗和预防的原因，有必要了解主要致敏物质的身份、它们的致敏能力以及交叉反应模式。PTBP - F - R中的单体，2 - 羟甲基对叔丁基苯酚（2 - MPTBP）和2,6 - 二羟甲基对叔丁基苯酚（2,6 - MPTBP），已被证明对人类具有接触致敏性。本研究的目的是通过豚鼠最大化试验研究这些单体的致敏能力，并在豚鼠中建立交叉反应模式。结果表明2,6 - MPTBP是一种强致敏剂，而2 - MPTBP是一种致敏剂。对2,6 - MPTBP致敏的动物对2 - MPTBP和对叔丁基邻苯二酚表现出交叉反应。对叔丁基苯酚、叔丁基对羟基茴香醚（BHA）和3,5 - 二叔丁基 - 4 - 羟基甲苯（BHT）未显示交叉反应。
