内皮受体酪氨酸激酶Tie2在口腔黏膜小叶状毛细血管瘤中的表达：一项免疫组织化学研究
Expression of the endothelial receptor tyrosine kinase Tie2 in lobular capillary hemangioma of the oral mucosa: an immunohistochemical study.
作者信息
Sato Hirotaka, Takeda Yasunori, Satoh Masanobu
机构信息
Department of Oral Pathology, School of Dentistry, Iwate Medical University, Morioka, Japan.
出版信息
J Oral Pathol Med. 2002 Aug;31(7):432-8. doi: 10.1034/j.1600-0714.2002.310708.x.
BACKGROUND
Lobular capillary hemangioma (LCH) usually occurs in the skin or mucous membranes as a rapidly growing red nodule. LCH is one of the most common vascular lesions in the oral mucosa. Tie2 is a novel, human endothelial receptor tyrosine kinase which may play an important role in blood vessel formation. In this study, we investigated its immunohistochemical expression in LCH of the oral mucosa.
METHODS
Double immunostaining with anti-CD34 and antialpha smooth muscle actin (SMA) antibodies was performed to characterize the cellular expression of Tie2 in 15 cases of this condition.
RESULTS
We found Tie2 immunoreactivity in the ovoid cells only, which were frequently intermingled with alphaSMA-positive cells, especially in the hypercellular portion of LCH.
CONCLUSIONS
These results suggest that the expression of Tie2 in ovoid cells and the interaction between ovoid cells and alphaSMA-positive cells play an important part in the development and progression of LCH.
背景
小叶状毛细血管瘤（LCH）通常表现为皮肤或黏膜上迅速生长的红色结节。LCH是口腔黏膜中最常见的血管病变之一。Tie2是一种新型的人类内皮受体酪氨酸激酶，可能在血管形成中起重要作用。在本研究中，我们调查了其在口腔黏膜LCH中的免疫组化表达。
方法
对15例该病患者进行抗CD34和抗α平滑肌肌动蛋白（SMA）抗体的双重免疫染色，以表征Tie2的细胞表达。
结果
我们仅在卵圆形细胞中发现Tie2免疫反应性，这些细胞常与αSMA阳性细胞混合，尤其是在LCH的细胞增多部分。
结论
这些结果表明，卵圆形细胞中Tie2的表达以及卵圆形细胞与αSMA阳性细胞之间的相互作用在LCH的发生和发展中起重要作用。
Zotero 插件