Voss C, Hartmann N
Acta Biol Med Ger. 1979;38(1):65-8.
Male Wistar rats on 3 or 50% fat diet for 14 weeks were treated during 6 weeks with L-thyroxine (5 or 25 or 50 microgram 100 g body weight/2 times weekly, sc.) and the activity of L-thyroxine-deiodinase was determined in supernatans of liver homogenates. With increasing thyroxine lading the deiodinating activity increases statistically significantly within each diet group. The liver of animals on 50% fat diet deiodinates increasing thyroxine doses to a lesser extent than livers of animals on 3% fat diet. It is discussed that high fat diet influences thyroid function and that thyroxine shares effectiveness and undergoes deiodination also in other tissues, probably in fat tissue, to a higher extent.
雄性Wistar大鼠分别给予3%或50%脂肪饮食14周，随后6周用L-甲状腺素（5、25或50微克/100克体重，每周皮下注射2次）进行处理，并测定肝匀浆上清液中L-甲状腺素脱碘酶的活性。在每个饮食组中，随着甲状腺素负荷增加，脱碘活性在统计学上显著增加。与3%脂肪饮食组动物的肝脏相比，50%脂肪饮食组动物的肝脏对增加的甲状腺素剂量进行脱碘的程度较小。本文讨论了高脂肪饮食对甲状腺功能的影响，以及甲状腺素在其他组织（可能在脂肪组织中程度更高）中同样具有有效性并发生脱碘。
