Li Chaomin, Bardhan Sujata, Pace Emily A, Liang Mei-Chih, Gilmore Thomas D, Porco John A
Department of Chemistry and Center for Streamlined Synthesis, Boston University, Massachusetts 02215, USA.
Org Lett. 2002 Sep 19;4(19):3267-70. doi: 10.1021/ol026513n.
[reaction: see text] The asymmetric synthesis of the natural product (+)-epoxyquinol A (1) and related epoxyquinoid dimers, employing a cascade oxidation/electrocyclization/Diels-Alder dimerization sequence, is reported. In addition, we show that 1 and related molecules inhibit activation of the transcription factor NF-kappaB.
[反应：见正文] 报道了采用级联氧化/电环化/狄尔斯-阿尔德二聚化序列对天然产物(+)-环氧喹诺醇A (1)及相关环氧喹诺类二聚体进行不对称合成。此外，我们还表明1及相关分子可抑制转录因子NF-κB的激活。
