新型核因子-κB抑制剂（-）-环氧化雪腐镰刀菌烯醇的全合成
Total synthesis of the novel NF-kappaB inhibitor (-)-cycloepoxydon.
作者信息
Mehta Goverdhan, Islam Kabirul
机构信息
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India.
出版信息
Org Lett. 2004 Mar 4;6(5):807-10. doi: 10.1021/ol036521j.
PMID:14986980
Abstract
An enantioselective total synthesis of the novel, biologically active epoxyquinone natural product (-)-cycloepoxydon has been accomplished from the readily available Diels-Alder adduct of cyclopentadiene and p-benzoquinone. A new cycloepoxydon related heptacyclic dimer has been prepared and characterized. [reaction: see text]
摘要
已从环戊二烯与对苯醌易于获得的狄尔斯-阿尔德加合物完成了新型生物活性环氧醌天然产物（-）-环环氧菌素的对映选择性全合成。制备并表征了一种新的与环环氧菌素相关的七环二聚体。[反应：见正文]
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