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本文引用的文献

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The Chemistry of Vicinal Diamines.邻二胺的化学
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High-throughput screening of identity, enantiomeric excess, and concentration using MLCT transitions in CD spectroscopy.利用圆二色光谱中的MLCT跃迁对身份、对映体过量和浓度进行高通量筛选。
J Am Chem Soc. 2008 Jul 23;130(29):9232-3. doi: 10.1021/ja803443j. Epub 2008 Jun 24.
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Enantioselective fluorescent recognition of chiral acids by cyclohexane-1,2-diamine-based bisbinaphthyl molecules.基于环己烷-1,2-二胺的双萘基分子对手性酸的对映选择性荧光识别
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Two methods for the determination of enantiomeric excess and concentration of a chiral sample with a single spectroscopic measurement.通过单次光谱测量测定手性样品对映体过量和浓度的两种方法。
Chemistry. 2007;13(1):99-104. doi: 10.1002/chem.200600402.
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The discovery of an enantioselective receptor for (-)-adenosine from a racemic dynamic combinatorial library.从外消旋动态组合库中发现(-)-腺苷的对映选择性受体。
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Pattern-based discrimination of enantiomeric and structurally similar amino acids: an optical mimic of the mammalian taste response.基于模式的对映体和结构相似氨基酸的鉴别：哺乳动物味觉反应的光学模拟。
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使用简单的外消旋金属配合物快速测定对映体过量和浓度

Rapid enantiomeric excess and concentration determination using simple racemic metal complexes.

作者信息

Nieto Sonia, Lynch Vincent M, Anslyn Eric V, Kim Hyunwoo, Chin Jik

机构信息

Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.

出版信息

Org Lett. 2008 Nov 20;10(22):5167-70. doi: 10.1021/ol802085j. Epub 2008 Oct 22.

DOI:10.1021/ol802085j
PMID:18939802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2749327/
Abstract

Racemic-metal complexes were used to determine identity, enantiomeric excess, and concentration of chiral diamines using metal-to-ligand charge transfer bands in circular dichroism spectroscopy. It takes under just 2 min per sample to determine [G]t and %R with tolerable errors (19% and 4%, respectively). The simplicity of the achiral receptors employed confers to this technique great potential for high-throughput screening.

摘要

外消旋金属配合物用于通过圆二色光谱中的金属-配体电荷转移带来确定手性二胺的身份、对映体过量和浓度。每个样品测定[G]t和%R只需不到2分钟，误差在可容忍范围内（分别为19%和4%）。所采用的非手性受体的简单性赋予了该技术在高通量筛选方面的巨大潜力。