Nieto Sonia, Lynch Vincent M, Anslyn Eric V, Kim Hyunwoo, Chin Jik
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
Org Lett. 2008 Nov 20;10(22):5167-70. doi: 10.1021/ol802085j. Epub 2008 Oct 22.
Racemic-metal complexes were used to determine identity, enantiomeric excess, and concentration of chiral diamines using metal-to-ligand charge transfer bands in circular dichroism spectroscopy. It takes under just 2 min per sample to determine [G]t and %R with tolerable errors (19% and 4%, respectively). The simplicity of the achiral receptors employed confers to this technique great potential for high-throughput screening.
外消旋金属配合物用于通过圆二色光谱中的金属-配体电荷转移带来确定手性二胺的身份、对映体过量和浓度。每个样品测定[G]t和%R只需不到2分钟,误差在可容忍范围内(分别为19%和4%)。所采用的非手性受体的简单性赋予了该技术在高通量筛选方面的巨大潜力。