Hang Jianfeng, Li Hongming, Deng Li
Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, USA.
Org Lett. 2002 Sep 19;4(19):3321-4. doi: 10.1021/ol026660l.
[reaction: see text] A rapid, highly efficient and general dynamic kinetic resolution (DKR) of racemic alpha-aryl UNCAs with the dual-function catalysis of modified cinchona alkaloid was accomplished at room temperature. This DKR led to the development of a highly enantioselective catalytic method for the practical synthesis of a wide range of alpha-aryl and alpha-heteroaryl amino acids in 89-92% ee and 86-95% yield from racemic UNCAs.
[反应：见正文] 在室温下，通过修饰金鸡纳生物碱的双功能催化实现了外消旋α-芳基未保护氨基酸（UNCAs）的快速、高效且通用的动态动力学拆分（DKR）。这种DKR促成了一种高对映选择性催化方法的开发，可从外消旋UNCAs以89 - 92%的对映体过量（ee）和86 - 95%的产率实际合成多种α-芳基和α-杂芳基氨基酸。
