Horvath Eva, Kovacs Kalman
Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, Toronto, Canada.
Ultrastruct Pathol. 2002 Jul-Aug;26(4):219-28. doi: 10.1080/01913120290104476.
Ultrastructural and immunocytochemical observations of pituitary folliculo-stellate cells (FSC) in a large series of adenomatous and nontumorous human pituitaries led to the following conclusions: (1) The endocrine cells of both the nontumorous and the adenomatous pituitary are capable of transforming into FSC while changing from endocrine to nonendocrine phenotype. (2) As shown on consecutive sections in prolactin cell adenomas with FSC-rich areas including microcyst formation, S-100 protein and glial fibrillary acidic protein (GFAP) immunoreactivities are strongest in the smallest newly formed follicles. The 2 immunoreactivities do not overlap. The epithelium of older microcysts is immunonegative, implying that expression of the 2 markers is restricted to the early phase of FSC formation. (3) Transformation of endocrine cells into FSC may signify retrodifferentiation into their Rathke's pouch derived precursors as suggested by occasional presence of ciliated and/or mucin producing cells in the lining of microcysts. (4) In lymphocytic hypophysitis a marked activation as well as increase of number and size of FSC are evident in areas of ongoing immune destruction supporting their immune role. (5) Considering the multifaceted nature of FSC, it is suggested that they represent a type of pluripotent adult stem cell.
对大量人类腺瘤性和非肿瘤性垂体中垂体滤泡星形细胞（FSC）进行的超微结构和免疫细胞化学观察得出以下结论：（1）非肿瘤性和腺瘤性垂体的内分泌细胞在从内分泌表型转变为非内分泌表型时都能够转化为FSC。（2）如在富含FSC区域（包括微囊肿形成）的催乳素细胞腺瘤的连续切片中所示，S-100蛋白和胶质纤维酸性蛋白（GFAP）免疫反应性在最小的新形成滤泡中最强。这两种免疫反应性不重叠。较老微囊肿的上皮呈免疫阴性，这意味着这两种标志物的表达仅限于FSC形成的早期阶段。（3）内分泌细胞向FSC的转化可能意味着向其源自拉特克囊的前体逆向分化，微囊肿内衬中偶尔出现的纤毛和/或产生黏液的细胞表明了这一点。（4）在淋巴细胞性垂体炎中，在正在进行免疫破坏的区域，FSC明显活化，数量和大小增加，这支持了它们的免疫作用。（5）考虑到FSC的多面性，有人提出它们代表一种多能成体干细胞。
