Tachibana O, Yamashima T
Department of Neurosurgery, University of Kanazawa School of Medicine, Japan.
Acta Neuropathol. 1988;76(5):458-64. doi: 10.1007/BF00686384.
Folliculo-stellate (FS) cells were studied in 102 human pituitary adenomas by immunohistochemical techniques using antibodies to S-100 protein and intermediate filaments protein. In most pituitary adenomas there were few S-100-positive cells, in contrast, numerous FS cells were found in four of the 54 cases of non-functioning adenomas. Among glial fibrillary acidic protein (GFAP), keratin and vimentin, FS cells showed greatest affinity to vimentin. Stains for desmin or neurofilaments were always negative. Counterstains with GFAP and keratin could demonstrate a small number of double-labelled cells, but mainly disclosed two types of FS cells positive for either GFAP or keratin. Accordingly, FS cells were grossly subdivided into two types: GFAP-positive cells which might be neuroectodermal or glial in origin and keratin-positive cells which might be oral ectodermal or derive from the Rathke's pouch.
采用抗S - 100蛋白抗体和中间丝蛋白抗体，通过免疫组化技术对102例人垂体腺瘤中的滤泡 - 星状（FS）细胞进行了研究。在大多数垂体腺瘤中，S - 100阳性细胞很少，相比之下，在54例无功能腺瘤中有4例发现了大量的FS细胞。在胶质纤维酸性蛋白（GFAP）、角蛋白和波形蛋白中，FS细胞对波形蛋白表现出最大的亲和力。结蛋白或神经丝的染色始终为阴性。GFAP和角蛋白复染可显示少量双标记细胞，但主要揭示了两种分别对GFAP或角蛋白呈阳性的FS细胞。因此，FS细胞大致可分为两种类型：可能起源于神经外胚层或神经胶质的GFAP阳性细胞，以及可能起源于口腔外胚层或拉特克囊的角蛋白阳性细胞。
