Ylikahri R H, Huttunen M O, Härkönen M, Leino T, Helenius T, Liewendahl K, Karonen S L
J Clin Endocrinol Metab. 1978 May;46(5):715-20. doi: 10.1210/jcem-46-5-715.
The plasma or serum concentrations of GH, TSH, LH, PRL, testosterone, cortisol, T4, and T3, and the values of the T3 uptake test were monitored in 12 healthy male volunteers for a period of 20 h after administration of one large dose of ethanol (1.5 g/kg BW). The effects of TRH and LRH on the secretion of TSH, PRL, and LH were studied in these subjects once during the period of acute alcohol intoxication (4 h after the start of drinking) and once during the hangover period (14 h after the start of drinking). Each subject served as his own control by drinking water only during another experimental session. Alcohol had no significant effect on basal concentrations of GH, TSH, LH, T4, T3, or testosterone. The concentration of cortisol in plasma was elevated during the whole 20-h period after ingestion of alcohol, as compared with the control values. Alcohol also did not significantly alter the effects of TRH and LRH on plasma TSH and LH levels at 4 and 14 h. During the hangover period, the PRL response to TRH was totally blocked, but during alcohol intoxication, there was a slight increase in the PRL response to TRH. The lack of response of PRL to TRH during the hangover suggests that withdrawal symptoms are associated with increased dopaminergic activity in the hypothalamus.
在12名健康男性志愿者中，给予一大剂量乙醇（1.5 g/kg体重）后20小时内，监测其血浆或血清中生长激素（GH）、促甲状腺激素（TSH）、促黄体生成素（LH）、催乳素（PRL）、睾酮、皮质醇、甲状腺素（T4）和三碘甲状腺原氨酸（T3）的浓度，以及T3摄取试验的值。在急性酒精中毒期间（饮酒开始后4小时）和宿醉期间（饮酒开始后14小时），对这些受试者研究促甲状腺激素释放激素（TRH）和促黄体生成素释放激素（LRH）对TSH、PRL和LH分泌的影响。在另一次实验期间，每个受试者仅通过饮水作为自身对照。酒精对GH、TSH、LH、T4、T3或睾酮的基础浓度无显著影响。与对照值相比，饮酒后整个20小时内血浆皮质醇浓度升高。酒精在4小时和14小时时也未显著改变TRH和LRH对血浆TSH和LH水平的影响。在宿醉期间，PRL对TRH的反应完全被阻断，但在酒精中毒期间，PRL对TRH的反应略有增加。宿醉期间PRL对TRH缺乏反应表明戒断症状与下丘脑多巴胺能活性增加有关。
