Rowland Jon M
Department of Pathology, Children's Hospital, Oakland, California 94609, USA.
Med Pediatr Oncol. 2002 Nov;39(5):478-83. doi: 10.1002/mpo.10171.
Comparison of outcomes in different clinicopathologic studies of hepatoblastoma requires reproducible histologic classification. This review examines the diagnostic criteria employed by different pathologists for the classification of subtypes of hepatoblastoma and identifies specific problem areas.
A selected review of published literature is provided.
Published studies demonstrate that uniform criteria have not been applied in the classification of hepatoblastoma. These discrepancies hinder attempts to compare outcome data from different studies. Sampling error and potential treatment effects further complicate analysis of the published literature on the relationship between morphologic classification and outcome.
Standardized criteria are essential to allow reproducible histologic classification of hepatoblastoma. There is significant variation in diagnostic criteria used to define the major subtypes of hepatoblastoma in published studies. Additional potential problems are identified in sampling methods and treatment effects.
肝母细胞瘤不同临床病理研究结果的比较需要可重复的组织学分类。本综述探讨了不同病理学家用于肝母细胞瘤亚型分类的诊断标准，并确定了具体的问题领域。
提供了对已发表文献的选定综述。
已发表的研究表明，肝母细胞瘤的分类尚未应用统一的标准。这些差异阻碍了比较不同研究结果数据的尝试。抽样误差和潜在的治疗效果使关于形态学分类与结果之间关系的已发表文献分析更加复杂。
标准化标准对于肝母细胞瘤可重复的组织学分类至关重要。在已发表的研究中，用于定义肝母细胞瘤主要亚型的诊断标准存在显著差异。在抽样方法和治疗效果方面还发现了其他潜在问题。
