Prokurat Andrzej, Kluge Przemysław, Kościesza Andrzej, Perek Danuta, Kappeler Andreas, Zimmermann Arthur
The Children's Memorial Health Institute, Warsaw, Poland.
Med Pediatr Oncol. 2002 Nov;39(5):510-8. doi: 10.1002/mpo.10177.
We encountered on seven malignant hepatocellular tumors developing in older children and adolescents.
These tumors exhibit an unusual phenotype with respect to clinical presentation, histopathology, immunohistochemistry, and treatment response. As a working hypothesis, we suggest that these apparently novel, unusual, and aggressive tumors occurring in older children and adolescents may form a transition in the putative developmental pathway of hepatocarcinogenesis.
We therefore propose the term, transitional liver cell tumors (TLCT), to denote these lesions.
我们遇到了7例发生于大龄儿童和青少年的恶性肝细胞肿瘤。
这些肿瘤在临床表现、组织病理学、免疫组化及治疗反应方面呈现出不同寻常的表型。作为一个可行的假设，我们认为这些明显新颖、异常且侵袭性强的肿瘤发生于大龄儿童和青少年，可能在推测的肝癌发生发展途径中构成一个过渡阶段。
因此，我们提出“过渡性肝细胞肿瘤（TLCT）”这一术语来指代这些病变。
