Prokurat Andrzej, Kluge Przemysław, Kościesza Andrzej, Perek Danuta, Kappeler Andreas, Zimmermann Arthur
The Children's Memorial Health Institute, Warsaw, Poland.
Med Pediatr Oncol. 2002 Nov;39(5):510-8. doi: 10.1002/mpo.10177.
We encountered on seven malignant hepatocellular tumors developing in older children and adolescents.
These tumors exhibit an unusual phenotype with respect to clinical presentation, histopathology, immunohistochemistry, and treatment response. As a working hypothesis, we suggest that these apparently novel, unusual, and aggressive tumors occurring in older children and adolescents may form a transition in the putative developmental pathway of hepatocarcinogenesis.
We therefore propose the term, transitional liver cell tumors (TLCT), to denote these lesions.
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