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1
A requirement for replication in activation of the ATR-dependent DNA damage checkpoint.
Genes Dev. 2002 Sep 15;16(18):2327-32. doi: 10.1101/gad.1013502.
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Study of the DNA damage checkpoint using Xenopus egg extracts.
J Vis Exp. 2012 Nov 5(69):e4449. doi: 10.3791/4449.
6
APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress.
Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10592-7. doi: 10.1073/pnas.1301445110. Epub 2013 Jun 10.
7
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.
Genes Dev. 2005 May 1;19(9):1040-52. doi: 10.1101/gad.1301205. Epub 2005 Apr 15.
8
Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures.
Genes Dev. 2006 Apr 1;20(7):772-83. doi: 10.1101/gad.1398806. Epub 2006 Mar 17.
10
The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1.
Genes Cells. 2006 Sep;11(9):993-1007. doi: 10.1111/j.1365-2443.2006.00998.x.

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2
Triple-Negative Breast Cancer and Emerging Therapeutic Strategies: ATR and CHK1/2 as Promising Targets.
Cancers (Basel). 2024 Mar 13;16(6):1139. doi: 10.3390/cancers16061139.
3
Implications of Translesion DNA Synthesis Polymerases on Genomic Stability and Human Health.
Mol Cell Biol. 2023;43(8):401-425. doi: 10.1080/10985549.2023.2224199. Epub 2023 Jul 13.
4
Organization of DNA Replication Origin Firing in Egg Extracts: The Role of Intra-S Checkpoint.
Genes (Basel). 2021 Aug 9;12(8):1224. doi: 10.3390/genes12081224.
5
A Tale of Ice and Fire: The Dual Role for 17β-Estradiol in Balancing DNA Damage and Genome Integrity.
Cancers (Basel). 2021 Mar 30;13(7):1583. doi: 10.3390/cancers13071583.
6
DNA Damage Response in Xenopus laevis Cell-Free Extracts.
Methods Mol Biol. 2021;2267:103-144. doi: 10.1007/978-1-0716-1217-0_8.
7
MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity.
Cell Rep. 2021 Mar 2;34(9):108808. doi: 10.1016/j.celrep.2021.108808.
8
Distinct roles of XRCC1 in genome integrity in Xenopus egg extracts.
Biochem J. 2019 Dec 23;476(24):3791-3804. doi: 10.1042/BCJ20190798.
9
Mechanisms of DNA Damage Tolerance: Post-Translational Regulation of PCNA.
Genes (Basel). 2018 Dec 24;10(1):10. doi: 10.3390/genes10010010.
10
APE2 promotes DNA damage response pathway from a single-strand break.
Nucleic Acids Res. 2018 Mar 16;46(5):2479-2494. doi: 10.1093/nar/gky020.

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1
The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint.
J Biol Chem. 2002 Jul 26;277(30):27088-93. doi: 10.1074/jbc.M204120200. Epub 2002 May 15.
2
A unified view of the DNA-damage checkpoint.
Curr Opin Cell Biol. 2002 Apr;14(2):237-45. doi: 10.1016/s0955-0674(02)00312-5.
4
ATR and ATRIP: partners in checkpoint signaling.
Science. 2001 Nov 23;294(5547):1713-6. doi: 10.1126/science.1065521.
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Two checkpoint complexes are independently recruited to sites of DNA damage in vivo.
Genes Dev. 2001 Nov 1;15(21):2809-21. doi: 10.1101/gad.903501.
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Cell cycle checkpoint signaling through the ATM and ATR kinases.
Genes Dev. 2001 Sep 1;15(17):2177-96. doi: 10.1101/gad.914401.
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Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication.
J Cell Biol. 2001 Mar 19;152(6):1267-78. doi: 10.1083/jcb.152.6.1267.
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The DNA damage response: putting checkpoints in perspective.
Nature. 2000 Nov 23;408(6811):433-9. doi: 10.1038/35044005.

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