Siegel Shepard, Ramos Barbara M C
Department of Psychology, McMaster University, Hamilton, Ontario, Canada.
Exp Clin Psychopharmacol. 2002 Aug;10(3):162-83. doi: 10.1037//1064-1297.10.3.162.
Basic research concerning drug tolerance and withdrawal may inform clinical practice, and vice versa. Three areas that integrate the work of the laboratory and the clinic are discussed: (a) drug overdose, (b) cue exposure treatment of addiction, and (c) pharmacological treatment of withdrawal symptoms. The areas are related in that they indicate the contribution of drug-paired cues to the effects of addictive drugs and the role of Pavlovian conditioning of drug effects in drug tolerance and withdrawal symptoms.
关于药物耐受性和戒断的基础研究可为临床实践提供参考，反之亦然。本文讨论了整合实验室与临床工作的三个领域：（a）药物过量，（b）成瘾的线索暴露疗法，以及（c）戒断症状的药物治疗。这些领域相互关联，因为它们表明了与药物配对的线索对成瘾性药物作用的影响，以及药物作用的巴甫洛夫条件反射在药物耐受性和戒断症状中的作用。
