Pascual-Pascual S I
Servicio de Neuropediatría. Hospital Universitario La Paz, Madrid, España.
Rev Neurol. 2002;35(3):269-76.
In last decade many advances have occurred in knowledge of pathogenic, in the different types of clinic expression and in the therapy of both acute and chronic polyneuritis.
To review the recent advances in the childhood expression of these disorders.
Into the broad term of Guillain-Barré syndrome (GBS) several types are considered: demyelinating, motor sensory axonal and motor axonal, and the Miller Fisher syndrome (MFS). Diagnostic criteria, clinical and neurophysiological are explained. The actual modes of treatment are reviewed, especially immunoglobulins and plasmapheresis. The chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare disease in childhood but it is necessary think on it when a picture of demyelinating polyneuropathy that seems the more frequent Charcot Marie Tooth type 1 polyneuropathy, because the treatment of CIDP changes radically the prognosis. Last advances of pathogenic, diagnostic criteria and treatment with corticosteroids, immunoglobulins and plasmapheresis are reviewed.
在过去十年中，我们对急性和慢性多发性神经炎的发病机制、不同类型的临床症状表现以及治疗方法都有了许多进展。
回顾这些疾病在儿童期的最新进展。
在广义的吉兰-巴雷综合征（GBS）中，包括几种类型：脱髓鞘型、运动感觉轴索性和运动轴索性，以及米勒-费希尔综合征（MFS）。文中解释了其诊断标准、临床及神经生理学表现。回顾了当前的治疗方式，尤其是免疫球蛋白和血浆置换。慢性炎症性脱髓鞘性多发性神经病（CIDP）在儿童期较为罕见，但当出现脱髓鞘性多发性神经病的症状，看似更常见的遗传性运动感觉性神经病1型（CMT1型）时，必须考虑到CIDP，因为其治疗会从根本上改变预后。文中回顾了CIDP的发病机制、诊断标准以及使用皮质类固醇、免疫球蛋白和血浆置换的治疗方法的最新进展。
