Ruts Liselotte, van Koningsveld Rinske, van Doorn Pieter A
Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.
Neurology. 2005 Jul 12;65(1):138-40. doi: 10.1212/01.wnl.0000167549.09664.b8.
Guillain-Barré syndrome (GBS) patients may worsen after initial treatment (treatment-related fluctuation [TRF]). It is difficult to distinguish GBS-TRF from chronic inflammatory demyelinating polyneuropathy with acute onset (A-CIDP). The authors compared 13 patients with A-CIDP with 11 patients with GBS-TRF and concluded that A-CIDP should be suspected when a patient with GBS deteriorates after 9 weeks from onset or when deterioration occurs three times or more. Maintenance treatment should then be considered.
吉兰-巴雷综合征（GBS）患者在初始治疗后可能病情恶化（治疗相关波动[TRF]）。很难将GBS-TRF与急性起病的慢性炎性脱髓鞘性多发性神经病（A-CIDP）区分开来。作者将13例A-CIDP患者与11例GBS-TRF患者进行了比较，得出结论：当GBS患者起病9周后病情恶化或恶化发生3次及以上时，应怀疑为A-CIDP。此时应考虑维持治疗。
