Odaka Masaaki, Yuki Nobuhiro, Hirata Koichi
Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321-0293, Japan.
J Neurol. 2003 Aug;250(8):913-6. doi: 10.1007/s00415-003-1096-y.
Progression periods for Guillain-Barré syndrome (GBS) differ from those of chronic inflammatory demyelinating polyneuropathy (CIDP), but physicians could classify patients with CIDP within 4 weeks of onset as GBS. We studied and report the frequency of GBS patients who were later diagnosed as CIDP (11/663, 2%). Plasmapheresis or intravenous immunoglobulin transiently improved all the 11 patients, who 11 progressed slowly or had a relapse beyond the 8 weeks, and the other 2 suffered a relapse between 4 and 8 weeks from the onset. Three patients had had an antecedent infectious illness. CSF albumino-cytological dissociation was detected in 6 patients within 2 weeks of onset. Recognition of the existence of such patients is important for the early diagnosis and treatment of those patients with CIDP for whom GBS has been diagnosed at onset.
吉兰-巴雷综合征（GBS）的进展期与慢性炎症性脱髓鞘性多发性神经病（CIDP）不同，但医生可能会在发病4周内将CIDP患者归类为GBS。我们进行了研究并报告了后来被诊断为CIDP的GBS患者的频率（11/663，2%）。血浆置换或静脉注射免疫球蛋白使所有11例患者得到短暂改善，其中11例进展缓慢或在8周后复发，另外2例在发病后4至8周内复发。3例患者有前驱感染病史。6例患者在发病2周内检测到脑脊液蛋白细胞分离。认识到这类患者的存在对于那些发病时被诊断为GBS但实际为CIDP的患者的早期诊断和治疗很重要。
