Batisse Dominique, Bazin Roland, Baldeweck Thérèse, Querleux Bernard, Lévêque Jean-Luc
L'Oréal Recherche, 90 rue du Général Roguet, Chevilly Larue, 92583 Clichy cedex, France.
Skin Res Technol. 2002 Aug;8(3):148-54. doi: 10.1034/j.1600-0846.2002.10308.x.
Comparisons of clinical assessment with measurement of physical parameters are rare.
To standardize the horizontal wrinkling of the skin in order to define a reference chart of the different wrinkling grades and to propose an interpretation of the clinical pattern in terms of skin layers thickness and mechanical parameters.
A device allowing reproducible wrinkling of the skin was made. The skin folds created in this way were clinically assessed on women of different ages. Measurements of the mechanical properties of the skin were carried out by using a Torquemeter. Skin layers' thicknesses were measured by using in vivo Confocal Microscopy (CM) and Ultrasound Imaging (B mode).
Skin wrinkling grades increase versus age. Skin elasticity, extensibility and echogenicity decrease also versus age and the wrinkling grade. Wrinkling appears to be related to skin rigidification (for both stratum corneum and dermis) coupled to a certain weakening of the upper dermis (loss of echogenicity).
This study points out the key role of the age-related alterations of the upper dermis in skin wrinkling capacities.
临床评估与身体参数测量的比较很少见。
规范皮肤的水平皱纹，以定义不同皱纹等级的参考图表，并根据皮肤层厚度和力学参数对临床模式提出一种解释。
制作了一种能使皮肤产生可重复皱纹的装置。以这种方式产生的皮肤褶皱在不同年龄的女性身上进行了临床评估。使用扭矩计对皮肤的力学性能进行测量。通过体内共聚焦显微镜（CM）和超声成像（B模式）测量皮肤层的厚度。
皮肤皱纹等级随年龄增加。皮肤弹性、伸展性和回声性也随年龄和皱纹等级降低。皱纹似乎与皮肤硬化（角质层和真皮均如此）以及上真皮层的某种弱化（回声性丧失）有关。
本研究指出了上真皮层与年龄相关的改变在皮肤皱纹形成能力中的关键作用。
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