Ortonne J P, Zartarian M, Verschoore M, Queille-Roussel C, Duteil L
Dermatology Department, Archet Hospital, Nice, France.
J Eur Acad Dermatol Venereol. 2008 Jul;22(7):827-34. doi: 10.1111/j.1468-3083.2007.02570.x. Epub 2008 Feb 27.
This study aimed to identify the characteristics of cellulite in women of different age and to appreciate whether cellulite could interfere with skin ageing or not.
94 Healthy females, divided into three age groups (21-30yrs; 31-40yrs; 51-60yrs) and two grade groups of cellulite (grade 2; grade 0 or control group), were investigated using non invasive techniques. The "orange peel appearance" was quantified by measuring the shadowed surfaces under low angle light. The biomechanichal properties were measured (extensibility-retractability-elasticity). The thicknesses of the skin structures were also evaluated using ultrasound. Echogenicity of the dermis was recorded and dermis density determined in two bands (superficial and low dermis).
In grade 2, the shadowed surfaces are significantly different according to age; i.e. smaller and more numerous after age of 30; the total skin thickness including hypodermis is increased of about 30% irrespective to age, compared to control group. The biomechanical properties of the skin are significantly modified as age increases without any grade effect. In grade 2, retractability and elasticity parameters are altered from age 30 whilst only from age 50 in the control group. Echogenicities of the superficial and deep dermis also decrease from age 30 and become significantly lower than the ones of grade 0.
Population with cellulite presents earlier skin ageing characteristics than the control population. Two sub-populations may exist: the under 30 age with large dimpled surfaces, normal biomechanical and density properties; and the over 30 age with smaller and numerous dimpled surfaces and already altered dermis properties. This premature skin ageing should be prevented accordingly.
本研究旨在确定不同年龄段女性橘皮组织的特征,并了解橘皮组织是否会干扰皮肤老化。
94名健康女性被分为三个年龄组(21 - 30岁;31 - 40岁;51 - 60岁)和两个橘皮组织等级组(2级;0级或对照组),采用非侵入性技术进行研究。通过测量低角度光线下的阴影面积来量化“橘皮外观”。测量生物力学特性(伸展性 - 回缩性 - 弹性)。还使用超声评估皮肤结构的厚度。记录真皮的回声性,并在两个区域(浅表真皮和深层真皮)确定真皮密度。
在2级中,阴影面积根据年龄有显著差异;即30岁以后面积更小且数量更多;与对照组相比,包括皮下组织在内的总皮肤厚度无论年龄如何均增加约30%。随着年龄增长,皮肤的生物力学特性有显著改变,且无等级效应。在2级中,回缩性和弹性参数从30岁起发生改变,而对照组仅从50岁起改变。浅表和深层真皮的回声性也从30岁起降低,并显著低于0级。
有橘皮组织的人群比对照组呈现出更早的皮肤老化特征。可能存在两个亚人群:30岁以下,有大的酒窝状表面,生物力学和密度特性正常;30岁以上,有更小且更多的酒窝状表面,真皮特性已改变。应相应地预防这种过早的皮肤老化。