Wong K F, So C C, Lau G
Department of Pathology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong SAR, China.
Cancer Genet Cytogenet. 2002 Jul 15;136(2):146-8. doi: 10.1016/s0165-4608(02)00531-9.
A 37-year-old woman that presented with cervical lymphadenopathy and leukocytosis was found to have precursor T-lymphoblastic leukemia (T-ALL). Cytogenetic study of the leukemic cells showed a 46,XX, t(1;22)(p34;q13) karyotype. The t(1;22)(p34;q13) is a novel chromosomal abnormality in human malignancies and is probably a variant form of the t(1;14)(p34;q11) found in precursor T-ALL.
一名37岁女性因颈部淋巴结病和白细胞增多就诊，被诊断为前体T淋巴细胞白血病（T-ALL）。对白血病细胞进行的细胞遗传学研究显示核型为46,XX,t(1;22)(p34;q13)。t(1;22)(p34;q13)是人类恶性肿瘤中一种新的染色体异常，可能是在前体T-ALL中发现的t(1;14)(p34;q11)的一种变异形式。
