Okereke Ndubueze C, Uvena-Celebrezze Jennifer, Hutson-Presley Larraine, Amini Saeid B, Catalano Patrick M
Department of Obstetrics and Gynecology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, Ohio 44109-1998, USA.
Am J Obstet Gynecol. 2002 Sep;187(3):798-803. doi: 10.1067/mob.2002.125887.
The purpose of this study was to determine the relationship of neonatal sex and gestational diabetes mellitus on cord leptin concentration and to determine whether cord leptin has a stronger correlation with fat mass compared with birth weight or lean body mass. We hypothesized that there are no significant differences in fetal leptin concentration between male and female or between neonates of mothers with gestational diabetes mellitus and control neonates, when adjusted for body composition.
Cord blood leptin concentrations were measured in newborn infants of 78 women (44 control neonates and 34 gestational diabetes mellitus). Of the 78 neonates, 32 babies were female, and 46 babies were male. Birth weights were measured with a calibrated scale, and body compositions were measured by total body electrical conductivity.
Estimated mean gestational age at delivery was 39.1 +/- 1.1 weeks for control neonates versus 38.6 +/- 1.3 weeks for neonates of mothers with gestational diabetes mellitus (P =.01). The fat mass for the control neonates and neonates of mothers with gestational diabetes mellitus was 0.36 +/- 0.15 kg versus 0.48 +/- 0.21 kg (P =.01); the percent body fat for the control neonates and neonates of mothers with gestational diabetes mellitus was 10.5% +/- 3.8% versus 13.2% +/- 4.3% (P =.006), respectively. There was no significant difference in cord leptin concentration between male and female neonates (16.0 +/- 13.8 ng/dL vs 12.7 +/- 12.8 ng/dL, P =.24). Cord leptin concentrations (18.1 +/- 16.2 ng/dL vs 10.9 +/- 9.5 ng/dL, P =.02) were significantly greater in neonates of mothers with gestational diabetes mellitus than in control neonates. In all subjects, cord leptin was significantly correlated with percent body fat (r = 0.51, P <.0001), fat mass (r = 0.49,P <.0001), and birth weight (r = 0.25, P =.03). After the adjustment for fat mass, there was no significant difference in cord leptin concentration between control neonates and neonates of mothers with gestational diabetes mellitus (P =.20), but there was a significant difference between male and female neonates (P =.04). However, when an adjustment was made for both fat mass and lean body mass, there was no longer a significant difference between male and female neonates (P =.12)
The differences in cord leptin concentration between male and female neonates and between infants of women with gestational diabetes mellitus and control neonates are related to differences in body composition.
本研究旨在确定新生儿性别和妊娠期糖尿病与脐带血瘦素浓度之间的关系，并确定与出生体重或瘦体重相比，脐带血瘦素与脂肪量之间是否具有更强的相关性。我们假设，在调整身体成分后，男性和女性胎儿或患有妊娠期糖尿病母亲的新生儿与对照新生儿之间的瘦素浓度无显著差异。
对78名女性的新生儿（44名对照新生儿和34名患有妊娠期糖尿病的新生儿）的脐带血瘦素浓度进行了测量。在这78名新生儿中，32名是女婴，46名是男婴。使用校准秤测量出生体重，通过全身电阻抗法测量身体成分。
对照新生儿的估计平均分娩孕周为39.1±1.1周，而患有妊娠期糖尿病母亲的新生儿为38.6±1.3周（P = 0.01）。对照新生儿和患有妊娠期糖尿病母亲的新生儿的脂肪量分别为0.36±0.15 kg和0.48±0.21 kg（P = 0.01）；对照新生儿和患有妊娠期糖尿病母亲的新生儿的体脂百分比分别为10.5%±3.8%和13.2%±4.3%（P = 0.006）。男、女新生儿脐带血瘦素浓度无显著差异（16.0±13.8 ng/dL对12.7±12.8 ng/dL，P = 0.24）。患有妊娠期糖尿病母亲的新生儿的脐带血瘦素浓度（18.1±16.2 ng/dL对10.9±9.5 ng/dL，P = 0.02）显著高于对照新生儿。在所有受试者中，脐带血瘦素与体脂百分比（r = 0.51，P < 0.0001）、脂肪量（r = 0.49，P < 0.0001）和出生体重（r = 0.25，P = 0.03）显著相关。在调整脂肪量后，对照新生儿和患有妊娠期糖尿病母亲的新生儿的脐带血瘦素浓度无显著差异（P = 0.20），但男、女新生儿之间存在显著差异（P = 0.04）。然而，当同时调整脂肪量和瘦体重时，男、女新生儿之间不再存在显著差异（P = 0.12）。
男、女新生儿以及患有妊娠期糖尿病母亲的婴儿与对照新生儿之间脐带血瘦素浓度的差异与身体成分的差异有关。
