Grupo de Investigación de Ciencias Básicas y Clínicas de la Salud, Departamento de Ciencias Básicas de la Salud, Pontificia Universidad Javeriana, Seccional-Cali, Cali, Colombia.
Grupo de investigación Salud y Movimiento, Facultad de Salud, Universidad Santiago de Cali, Cali, Colombia.
Biol Sex Differ. 2022 Sep 5;13(1):47. doi: 10.1186/s13293-022-00454-y.
Differences in adolescents and adults by sex in blood levels of leptin and adiposity have been described; however, it is not yet clear if these differences arise from the prepubertal stage in subjects with a normal-weight. Therefore, we examine whether there are differences by sex in levels of blood leptin and adiposity in children with a normal-weight between 0 and 10 years old.
Search strategy: eligible studies were obtained from three electronic databases (Ovid, Embase and LILACS) and contact with experts.
healthy children up to 10 years of age with normal-weight according to age.
data were extracted by four independent reviewers using a predesigned data collection form. For the analysis, we stratified according to age groups (newborns, 0.25-0.5 years, 3-5.9 years, 6-7.9 years, 8-10 years). The statistical analysis was performed in the R program.
Of the initially identified 13,712 records, 21 were selected in the systematic review and meta-analysis. The sex was associated with the overall effect on blood leptin (pooled MD = 1.72 ng/mL, 95% CI: 1.25-2.19) and body fat percentage (pooled MD = 3.43%, 95% CI: 2.53-4.33), being both higher in girls. This finding was consistent in the majority of age groups.
The results of our meta-analyses support the sexual dimorphism in circulating blood leptin and body fat percentage between girls and boys with normal-weight from prepuberty.
已有研究描述了青少年和成年人的瘦素和肥胖程度在性别上存在差异；然而，目前尚不清楚这些差异是否源于正常体重的受试者的青春期前阶段。因此，我们研究了 0 至 10 岁正常体重儿童的血液瘦素和肥胖程度是否存在性别差异。
搜索策略：从三个电子数据库（Ovid、Embase 和 LILACS）和专家联系中获取符合条件的研究。
健康的儿童，年龄在 10 岁以下，体重正常。
四名独立的评审员使用预先设计的数据收集表提取数据。为了分析，我们根据年龄组（新生儿、0.25-0.5 岁、3-5.9 岁、6-7.9 岁、8-10 岁）进行分层。统计分析在 R 程序中进行。
最初确定的 13712 条记录中，有 21 条在系统评价和荟萃分析中被选中。性别与血液瘦素的总体效应（汇总 MD=1.72ng/mL，95%CI：1.25-2.19）和体脂肪百分比（汇总 MD=3.43%，95%CI：2.53-4.33）相关，女孩的这两个指标均较高。这一发现在大多数年龄组中都是一致的。
我们的荟萃分析结果支持青春期前正常体重的女孩和男孩的循环血液瘦素和体脂肪百分比存在性别二态性。
