Suyenaga E S, Reche E, Farias F M, Schapoval E E S, Chaves C G M, Henriques A T
Graduate Course in Pharmacy, Faculty of Pharmacy, UFRGS, Av. Iptranga 2752, 90.610.000 Porto Alegre, RS, Brazil.
Phytother Res. 2002 Sep;16(6):519-23. doi: 10.1002/ptr.908.
Mikania laevigata Schultz Bip. ex Baker, M. involucrata Hook. et Arn. and M. hirsutissima DC. (Asteraceae), commonly occurring in the southern Brazilian State of Rio Grande do Sul, were submitted to biological tests to evaluate their potential antiinflammatory activity. Decoctions from the leaves and stems were analysed by the induced rat paw oedema and pleurisy models. The animals were treated orally with different decoction doses. In the induced rat paw oedema test, the animals treated with leaf decoctions from M. laevigata (200 mg/ kg) and M. involucrata (50 mg/ kg) presented an oedema inhibition of 81.56% and 81.67%, respectively, 3 h after the administration of the phlogistic agent. Leaf decoctions from M. hirsutissima (400 mg/ kg) did not show such an activity. Stem decoctions displayed lower antiinflammatory activity when compared with the same doses and response time of the leaf decoctions for all analysed species. In the pleurisy assay, leaf decoctions from M. laevigata (400 mg/ kg) and M. involucrata (200 mg/ kg) inhibited leukocyte migration to the pleural exudate by 28.26% and 54.35%, respectively.
光叶薇甘菊（Mikania laevigata Schultz Bip. ex Baker）、总苞薇甘菊（M. involucrata Hook. et Arn.）和毛薇甘菊（M. hirsutissima DC.）（菊科）常见于巴西南部的南里奥格兰德州，对其进行了生物学试验以评估它们潜在的抗炎活性。采用大鼠足趾肿胀和胸膜炎模型对叶和茎的水煎剂进行分析。动物口服不同剂量的水煎剂。在大鼠足趾肿胀试验中，给予致炎剂3小时后，用200毫克/千克光叶薇甘菊叶水煎剂和50毫克/千克总苞薇甘菊叶水煎剂处理的动物足趾肿胀抑制率分别为81.56%和81.67%。400毫克/千克毛薇甘菊叶水煎剂未显示出这种活性。与所有分析物种相同剂量和反应时间的叶水煎剂相比，茎水煎剂的抗炎活性较低。在胸膜炎试验中，400毫克/千克光叶薇甘菊叶水煎剂和200毫克/千克总苞薇甘菊叶水煎剂分别使白细胞向胸膜渗出液的迁移抑制了28.26%和54.35%。
