Facilitation of the long term memory store with strychnine: a reexamination.

Contrary to previous findings, some recent studies have reported that several daily injections of strychnine, beginning 24 hr after learning, facilitates subsequent retention. The present paper reports 3 studies using mice which suggest that strychnine has no effect on retention when the learning-injection interval is 24 hr. This absence of an effect was found using a range of strychnine doses. Furthermore, the absence of the facilitation effect was found not to be due to any failure of animals to learn prior to injection or to the fact that all animals performed asymptotically on the retention test.