Brennan M J, Gordon W C
Pharmacol Biochem Behav. 1977 Nov;7(5):451-7. doi: 10.1016/0091-3057(77)90213-1.
In two experiments, the effects of strychnine on the specific memory attributes of prior discrimination training were assessed in terms of subjects' performance under various discrimination reversal conditions. Mice were trained in a discrimination task with two redundant relevant cues. Immediately after their last training trial, subjects were administered an intraperitoneal injection of either strychnine (1.0 mg/kg) or saline. When both training cues were reversed (Experiment 1), strychnine treated subjects were observed to exhibit greater performance decrements than saline-treated subjects upon initial exposure to reversal conditions, suggesting that strychnine had enhanced the memory of a relatively specific stimulus-response association. When subjects were tested under partial cue-reveraal conditions (Experiment 2) strychnine treated animals exhibited treater utilization of one of the redundant relevant stimuli than the other, while saline-treated animals exhibited no preference.
在两项实验中，根据受试者在各种辨别逆转条件下的表现，评估了士的宁对先前辨别训练的特定记忆属性的影响。小鼠在具有两个冗余相关线索的辨别任务中接受训练。在它们的最后一次训练试验后，立即给受试者腹腔注射士的宁（1.0毫克/千克）或生理盐水。当两个训练线索都被逆转时（实验1），观察到士的宁处理的受试者在最初接触逆转条件时比生理盐水处理的受试者表现出更大的性能下降，这表明士的宁增强了相对特定的刺激-反应关联的记忆。当受试者在部分线索逆转条件下进行测试时（实验2），士的宁处理的动物对其中一个冗余相关刺激的利用比另一个更多，而生理盐水处理的动物没有表现出偏好。
