Shugalev N P, Ol'shanskii A S, Hartmann G
Science Research Institute of the Brain, Russian Academy of Medical Sciences, Moscow.
Neurosci Behav Physiol. 2002 Jul-Aug;32(4):375-8. doi: 10.1023/a:1015876110276.
The studies reported here demonstrate that microinjection of neurotensin into the caudate nucleus of the rat brain facilitated extinction of a conditioned motor reflex with reinforcement provided by drinking. Neurotensin had positive effects on the process of post-extinction inhibition in subsequent experiments. Neurotensin microinjections had no marked effect on the performance of the conditioned reflex, though it weakened the emotional tension of the animals in an "open field" test. It is concluded that the functional importance of neurotensin at the level of the caudate nucleus is associated less with the regulation of motor function than with optimizing the motivational-emotional state of the animal.
此处报道的研究表明，向大鼠脑尾状核微量注射神经降压素可促进由饮水提供强化的条件性运动反射的消退。在后续实验中，神经降压素对消退后抑制过程有积极作用。微量注射神经降压素对条件反射的表现没有显著影响，不过在“旷场”试验中它减弱了动物的情绪紧张。得出的结论是，神经降压素在尾状核水平的功能重要性与其对运动功能的调节关系较小，而与优化动物的动机 - 情绪状态有关。
