Kiss J, Faragó E, Gömöry A, Czakó Z, Fäbiän E, Bacsa S
Acta Chir Acad Sci Hung. 1975;16(4):351-7.
The antibiotic level in the serum, pericardial fluid and myocardium of 11 patients prepared for heart surgery was tested by means of the agar-diffusion method after the intramuscular administration of 1 g of methicillin. The mean level after 1 to 3 hours was 14.7 mcg/ml in serum, 1.7 mcg/ml in the pericardial fluid and 8.2 mcg/g in the myocardium. In the case of drug sensitivity, the myocardial methicillin concentration is sufficient for the treatment of Gram-positive infections. If the infection is localized in the pericardium, higher doses, local applications, drug combination or complex therapy might be called for.
对11例准备进行心脏手术的患者，在肌肉注射1克甲氧西林后，采用琼脂扩散法检测其血清、心包液和心肌中的抗生素水平。1至3小时后的平均水平为：血清中14.7微克/毫升，心包液中1.7微克/毫升，心肌中8.2微克/克。就药物敏感性而言，心肌中的甲氧西林浓度足以治疗革兰氏阳性菌感染。如果感染局限于心包，则可能需要更高剂量、局部应用、联合用药或综合治疗。
