Kiss J, Faragó E, Gömöry A, Homolay P, Kiss I S
Acta Chir Acad Sci Hung. 1977;18(2):133-9.
Gentamycin concentration in the serum, pericardial fluid, auricle, valve and papillary muscles of 14 patients subjected to cardiac surgery was determined after intramuscular administration of 80 mg of the drug. Fifty to 140 minutes after administration the mean level in the serum was 6.0 mcg/ml, in the pericardial fluid 0.6 mcg/ml, in the auricle 5.8 mcg/g, while after 120 to 240 minutes in the valve 1.2--9.6 mcg/g and in the papillary muscles 2.0--3.6 mcg/g of gentamycin was measured. Consequently, an efficacious gentamycin concentration can be achieved in the cardiac tissues but not in the pericardial fluid which makes gentamycin excellently suited for the prevention and treatment of the infectious complications of heart operations.
对14例接受心脏手术的患者肌肉注射80毫克庆大霉素后，测定了其血清、心包液、心耳、瓣膜和乳头肌中的庆大霉素浓度。给药后50至140分钟，血清中的平均水平为6.0微克/毫升，心包液中为0.6微克/毫升，心耳中为5.8微克/克，而在120至240分钟后，瓣膜中的庆大霉素含量为1.2 - 9.6微克/克，乳头肌中为2.0 - 3.6微克/克。因此，心脏组织中可达到有效的庆大霉素浓度，但心包液中则不然，这使得庆大霉素非常适合预防和治疗心脏手术的感染性并发症。
