Corry W D, Meiselman H J
Department of Physiology, University of Southern California, School of Medicine, Los Angeles 90033.
Blood Cells. 1978;4(3):465-83.
The effects of low levels of glutaraldehyde uptake (less than 120 mumol/10(10) cells) on the physicochemical properties of human red blood cells (RBC) were investigated. Salient effects include: by different measures of cell deformability, the extent of glutaraldehyde uptake required to decrease cellular deformability was shown to range from approximately 8 to 30 mumol/10(10) cells; osmotically stressed red cells exhibit complete hemolysis when the level of glutaraldehyde uptake is less than 28 mumol/10(10) cells and no hemolysis when uptake is less than 70 mumol/10(10) cells with the extent of hemolysis decreasing in an approximately linear manner with glutaraldehyde uptake between these limits; glutaraldehyde uptake of up to 58 mumol/10(10) cells does not change the cells' density, mean cell volume or ability to retain potassium.
研究了低水平戊二醛摄取量（低于120μmol/10¹⁰个细胞）对人红细胞（RBC）理化性质的影响。显著影响包括：通过不同的细胞变形性测量方法，降低细胞变形性所需的戊二醛摄取程度显示为约8至30μmol/10¹⁰个细胞；当戊二醛摄取量低于28μmol/10¹⁰个细胞时，渗透压应激红细胞会发生完全溶血，而当摄取量低于70μmol/10¹⁰个细胞时则无溶血现象，在这些限度之间，溶血程度随戊二醛摄取量以近似线性方式降低；高达58μmol/10¹⁰个细胞的戊二醛摄取量不会改变细胞的密度、平均细胞体积或保留钾的能力。
