Demichenko A N, Serdechnaia L I
Probl Endokrinol (Mosk). 1975 Jul-Aug;21(4):31-4.
A reduction of testosterone excretion in men with hypogonadism is reported in literature; however, the clinical peculiarity of its individual forms are not considered in these works. This paper treats of testosterone excretion in 43 patients with various forms of hypogonadism, of this number in 36 before and after a single testosterone-propionate loading. There was seen a reduction of testosterone excretion in hypogonadism. Secondary hypogonadism coursed against the background of a more marked insufficiency of testosterone excretion than the primary one. In a number of hypogonadism cases testosterone excretion remained unchanged and their clinical signs were caused by an inadequate realization of the androgenic effect. In hypogonadism an increase of the urinary excretion following its administration did not always correspond to the dose of the administered hormone, which could serve as one of the pathogenetic mechanisms of development of the disease.
文献报道性腺功能减退男性的睾酮排泄量会降低；然而，这些研究并未考虑其个体形式的临床特点。本文探讨了43例各种形式性腺功能减退患者的睾酮排泄情况，其中36例在单次注射丙酸睾酮前后进行了检测。结果发现性腺功能减退患者的睾酮排泄量降低。继发性性腺功能减退患者睾酮排泄不足的程度比原发性性腺功能减退更为明显。在一些性腺功能减退病例中，睾酮排泄量保持不变，其临床症状是由雄激素作用未充分发挥所致。在性腺功能减退患者中，给予睾酮后尿排泄量的增加并不总是与所给予激素的剂量相对应，这可能是该疾病发生发展的发病机制之一。
