Demchenko A N, Serdechnaia L I
Probl Endokrinol (Mosk). 1977 Mar-Apr;23(2):43-7.
The authors present the results of determination of the testosterone and androstendion excretion in the patients with various forms of hypogonadism and in healthy men. Testosterone excretion was decreased in the patients with hypogonadism, against the background of normal or increased androstendion excretion whereas the degree of deviations of the testosterone/androstendion ratio depended on the clinical variant of hypogonadism. Thus, retarded or decreased accumulation of the enzymes in the testes responsible for the change from the "child" to the "mature" type of steroid biosynthesis could serve as a mechanism of hypogonadism occurrence, which should be taken into consideration in the elaboration of the methods of syndrome therapy of this type of pathology.
作者介绍了不同类型性腺功能减退患者及健康男性体内睾酮和雄烯二酮排泄量的测定结果。性腺功能减退患者的睾酮排泄量降低，而雄烯二酮排泄量正常或增加，睾酮/雄烯二酮比值的偏差程度取决于性腺功能减退的临床类型。因此，睾丸中负责从“儿童”型向“成熟”型类固醇生物合成转变的酶积累延迟或减少可能是性腺功能减退发生的机制，在制定这类病理综合征的治疗方法时应予以考虑。
