Demchenko A N, Demchenko S V, Serdechnaia L I
Probl Endokrinol (Mosk). 1975 Sep-Oct;21(5):46-9.
The work is a clinico-laboratory study and and treats of the results of determination of gonadotropine excretion before and after the administration of testosterone to the patients with various forms of hypogonadism. The prevailing effect of testosterone on the excretion of the gonadotropic hormones could be blocking, stimulating or neutral depending on the clinical variant of hypogonadism. Thus, a change of sensitivity of the central link in the hypophysis-gonad system to the action of the peripheral hormones could apparently be of definite significance in the pathogenesis of hypogonadism; this should be taken into consideration in the elaboration of rational schemes of its therapy.
这项工作是一项临床实验室研究，涉及对各种类型性腺功能减退患者在给予睾酮前后促性腺激素排泄测定结果的研究。睾酮对促性腺激素排泄的主要作用可能是阻断、刺激或无影响，这取决于性腺功能减退的临床类型。因此，垂体 - 性腺系统中枢环节对外周激素作用的敏感性变化在性腺功能减退的发病机制中显然具有一定意义；在制定其合理治疗方案时应考虑到这一点。
