Kammermeier H, Kammermeier B
Recent Adv Stud Cardiac Struct Metab. 1975;7:61-7.
Data of tracer wash-out kinetics of substrates and other substances permit the calculation of myocardial capillary exchange rates. Transfer rates calculated from these data and from known plasms substrate concentrations are close to the extraction rates observed by several authors. The substrate pattern offered for the myocardial cell, calculated from the capillary transfer, is also very similar to that extracted. These findings indicate that myocardial substrate consumption is determined and, under certain circumstances, even limited by capillary exchange. Limitation of capillary substrate transfer might act as a bottleneck of myocardial energy metabolism and might induce myocardial cell necrosis under certain conditions.
底物及其他物质的示踪剂洗脱动力学数据有助于计算心肌毛细血管交换率。根据这些数据以及已知的血浆底物浓度计算出的转运率，与几位作者观察到的提取率相近。根据毛细血管转运计算得出的为心肌细胞提供的底物模式，也与提取的模式非常相似。这些发现表明，心肌底物消耗是由毛细血管交换决定的，在某些情况下甚至受其限制。毛细血管底物转运的限制可能成为心肌能量代谢的瓶颈，并在某些条件下诱发心肌细胞坏死。
